Botanical Source:             Pausinystalia Yohimbe

Used Part:                          Bark

Specification:                     2%,.4%,8%,98% yohimbine

Analysis:                             HPLC

Function of Yohimbe Extract

Men’s health，the treatment of male erectile dysfunction (ED).

Sources of Yohimbe Extract

It is extracted from the bark of Pausinystalia yohimbe in Africa.The bark of the tree contains the active compounds called alkaloids. The principal alkaloid is called yohimbine,which widely used for ccuring sexual dysfunction that resulted from tension,pressure and fatigue.It could speed energy circulation of body to increase the energy supply.Yohimbine has been used as both an over-the-counter dietary supplement in herbal extract form and prescription medicine in pure form for the treatment of sexual dysfunction.

Ingredients of Yohimbe Extract

Yohimbine, an alpha-2 adrenoceptor antagonist, is an indole alkaloid found in numerous botanical sources. It is the predominant alkaloid in extracts from the bark of the Pausinystalia yohimbe tree, and can also be found in Rauwolfia root. Yohimbine has two stereoisomers (rauwolscine and corynanthine) that differ little in their physical properties or in their effects on serotonin and dopamine receptors. The three isomers, however, do differ significantly in their affinity for the alpha-1 and alpha-2 adrenoceptor subtypes. [3H]Yohimbine was one of the first radioligands developed for selectively labeling alpha-2 adrenoceptors 1.

Yohimbine
CAS: 146-48-5
Structural formula:

Molecular formula:C21H26N2O3
Molecular Weight: 354.44

Specification of Yohimbe Extract

Study of Yohimbe Extract

Although yohimbine (YOH) has been available for the treatment of male erectile dysfunction (ED) for longer than Viagra®, there is a perception that little is known about the clinical performance of the drug. This review attempts, by comprehensive analysis of the literature, to cover the clinical, pharmacological, and therapeutic profiles of YOH, relevant to its potential utility in the management of patients with ED. Relatively few well-designed studies have been completed. From these, however, it can be concluded that YOH as monotherapy possesses only modest efficacy in ED patients. In acute and chronic (long-term) studies, YOH has been found to be relatively free of side effects over the dose range predicted to be effective in ED. At much higher doses, the most frequently observed effects, consistent with the primary pharmacological action of the drug, are elevation of blood pressure, a slight anxiogenic action, and increased frequency of urination. These side effects are all easily reversible on termination of YOH therapy. There is increasing evidence that the erectogenic action of YOH can be augmented by concomitant administration of agents that augment the release and/or action of nitric oxide in the corpus cavernosum. YOH has yet to be studied in female sexual dysfunction. Overall, the benefit risk profile of YOH would indicate that it has potential, more probably as part of a combination strategy, e.g., with a drug that enhances the nitric oxide pathway, in the treatment of ED 2

Reference of Yohimbe Extract

1 David B. Bylund,Yohimbine,xPharm: The Comprehensive Pharmacology Reference,2007, Pages 1–5

2 S.William Tam,Manuel Worcel,Michael Wyllie,Yohimbine: a clinical review,Pharmacology & Therapeutics,2001,91(3):215-243