Details of Yohimbe Bark Extract:

Botanical Source:             Pausinystalia Yohimbe

Used Part:                          Bark

Specification:                     2%,.4%,8%,98% yohimbine

Analysis:                             HPLC

Function of Yohimbe Bark Extract:

Men’s health, the treatment of male erectile dysfunction (ED).

Sources of Yohimbe Bark Extract

It is extracted from the bark of Pausinystalia yohimbe in Africa.The bark of the tree contains the active compounds called alkaloids. The principal alkaloid is called yohimbine,which widely used for ccuring sexual dysfunction that resulted from tension,pressure and fatigue.It could speed energy circulation of body to increase the energy supply.Yohimbine has been used as both an over-the-counter dietary supplement in herbal extract form and prescription medicine in pure form for the treatment of sexual dysfunction.

Ingredients of Yohimbe Bark Extract

Yohimbine, an alpha-2 adrenoceptor antagonist, is an indole alkaloid found in numerous botanical sources. It is the predominant alkaloid in extracts from the bark of the Pausinystalia yohimbe tree, and can also be found in Rauwolfia root. Yohimbine has two stereoisomers (rauwolscine and corynanthine) that differ little in their physical properties or in their effects on serotonin and dopamine receptors. The three isomers, however, do differ significantly in their affinity for the alpha-1 and alpha-2 adrenoceptor subtypes. [3H]Yohimbine was one of the first radioligands developed for selectively labeling alpha-2 adrenoceptors 1.

Yohimbine
CAS: 146-48-5
Structural formula:

Molecular formula:C21H26N2O3
Molecular Weight: 354.44

Specification of Yohimbe Bark Extract

 

ANALYSIS	SPECIFICATION
Appearance	Red-Brown Fine Powder
Odor	Characteristic
Assay (HPLC)	Yohimbine≥8.0%
Sieve analysis	100% pass 80 mesh
Loss on Drying	≤5.0%
Ash	≤5.0%
Heavy Metal	<10ppm
Pb	<2ppm
As	<2ppm
Hg	<2ppm
Residual Solvent	Eur.Pharm
Microbiology
Total Plate Count	<1000cfu/g
Yeast & Moulds	<100cfu/g
E.Coli	Negative
Salmonella	Negative

 

Study of Yohimbe Bark Extract

Although yohimbine (YOH) has been available for the treatment of male erectile dysfunction (ED) for longer than Viagra®, there is a perception that little is known about the clinical performance of the drug. This review attempts, by comprehensive analysis of the literature, to cover the clinical, pharmacological, and therapeutic profiles of YOH, relevant to its potential utility in the management of patients with ED. Relatively few well-designed studies have been completed. From these, however, it can be concluded that YOH as monotherapy possesses only modest efficacy in ED patients. In acute and chronic (long-term) studies, YOH has been found to be relatively free of side effects over the dose range predicted to be effective in ED. At much higher doses, the most frequently observed effects, consistent with the primary pharmacological action of the drug, are elevation of blood pressure, a slight anxiogenic action, and increased frequency of urination. These side effects are all easily reversible on termination of YOH therapy. There is increasing evidence that the erectogenic action of YOH can be augmented by concomitant administration of agents that augment the release and/or action of nitric oxide in the corpus cavernosum. YOH has yet to be studied in female sexual dysfunction. Overall, the benefit risk profile of YOH would indicate that it has potential, more probably as part of a combination strategy, e.g., with a drug that enhances the nitric oxide pathway, in the treatment of ED 2

Reference of Yohimbe Bark Extract

1 David B. Bylund,Yohimbine,xPharm: The Comprehensive Pharmacology Reference,2007, Pages 1–5

2 S.William Tam,Manuel Worcel,Michael Wyllie,Yohimbine: a clinical review,Pharmacology & Therapeutics,2001,91(3):215-243

About FineSky

Xi’an FineSky Technological Co.,Ltd. is a Chinese manufacturer dedicated to the research and development of natural products which is a market oriented, technology-driven high-tech enterprise. The company devotes to the commercialization of natural products. FineSky shows strong production ability and could supply many kinds of plant extract.Our products have been exported to many countries in the world.We have excellent R&D Capabilities,Strict quality control system and experienced team.We believe we have the capability to supply premier products .

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