• Yohimbe Bark Extract

  • Botanical Source:             Pausinystalia Yohimbe

    Used Part:                          Bark

    Specification:                     2%,.4%,8%,98% yohimbine

    Analysis:                             HPLC

    Function of Yohimbe Bark Extract

    Men’s health,the treatment of male erectile dysfunction (ED).



    Sources of Yohimbe Bark Extract

    It is extracted from the bark of Pausinystalia yohimbe in Africa.The bark of the tree contains the active compounds called alkaloids. The principal alkaloid is called yohimbine,which widely used for ccuring sexual dysfunction that resulted from tension,pressure and fatigue.It could speed energy circulation of body to increase the energy supply.Yohimbine has been used as both an over-the-counter dietary supplement in herbal extract form and prescription medicine in pure form for the treatment of sexual dysfunction.



    Ingredients of Yohimbe Bark Extract

    Yohimbine, an alpha-2 adrenoceptor antagonist, is an indole alkaloid found in numerous botanical sources. It is the predominant alkaloid in extracts from the bark of the Pausinystalia yohimbe tree, and can also be found in Rauwolfia root. Yohimbine has two stereoisomers (rauwolscine and corynanthine) that differ little in their physical properties or in their effects on serotonin and dopamine receptors. The three isomers, however, do differ significantly in their affinity for the alpha-1 and alpha-2 adrenoceptor subtypes. [3H]Yohimbine was one of the first radioligands developed for selectively labeling alpha-2 adrenoceptors 1.

    Yohimbine
    CAS: 146-48-5
    Structural formula:


    Molecular formula:C21H26N2O3
    Molecular Weight: 354.44



    Specification of Yohimbe Bark Extract

     

    ANALYSIS 

    SPECIFICATION 

    Appearance 

    Red-Brown Fine Powder 

    Odor 

    Characteristic 

    Assay (HPLC)

    Yohimbine≥8.0%

    Sieve analysis 

    100% pass 80 mesh 

    Loss on Drying 

    ≤5.0%

    Ash

    ≤5.0%

    Heavy Metal 

    <10ppm

    Pb

    <2ppm

    As 

    <2ppm

    Hg

    <2ppm

    Residual Solvent

    Eur.Pharm

    Microbiology 

    Total Plate Count 

    <1000cfu/g

    Yeast & Moulds 

    <100cfu/g

    E.Coli 

    Negative 

    Salmonella 

    Negative 

     



    Study of Yohimbe Bark Extract

    Although yohimbine (YOH) has been available for the treatment of male erectile dysfunction (ED) for longer than Viagra®, there is a perception that little is known about the clinical performance of the drug. This review attempts, by comprehensive analysis of the literature, to cover the clinical, pharmacological, and therapeutic profiles of YOH, relevant to its potential utility in the management of patients with ED. Relatively few well-designed studies have been completed. From these, however, it can be concluded that YOH as monotherapy possesses only modest efficacy in ED patients. In acute and chronic (long-term) studies, YOH has been found to be relatively free of side effects over the dose range predicted to be effective in ED. At much higher doses, the most frequently observed effects, consistent with the primary pharmacological action of the drug, are elevation of blood pressure, a slight anxiogenic action, and increased frequency of urination. These side effects are all easily reversible on termination of YOH therapy. There is increasing evidence that the erectogenic action of YOH can be augmented by concomitant administration of agents that augment the release and/or action of nitric oxide in the corpus cavernosum. YOH has yet to be studied in female sexual dysfunction. Overall, the benefit risk profile of YOH would indicate that it has potential, more probably as part of a combination strategy, e.g., with a drug that enhances the nitric oxide pathway, in the treatment of ED 2



    Reference of Yohimbe Bark Extract

    1 David B. Bylund,Yohimbine,xPharm: The Comprehensive Pharmacology Reference,2007, Pages 1–5

    2 S.William Tam,Manuel Worcel,Michael Wyllie,Yohimbine: a clinical review,Pharmacology & Therapeutics,2001,91(3):215-243


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