Details of Sophora Root Extract:

Product Name	Sophora flavescens Extract
Known As	Kuh-seng Extract
Latin Name	Sophora flavesecens Ait.
Effective Ingredient	Matrine 10%-98%
PART USED	Root
Appearance	Brown or white fine powder
SPECIFICATION	Matrine 10%-98% Test By HPLC
CAS NO.	519-02-8
MOLECULAR FORMULA	C15H24N2O
MOLECULAR WEIGHT	248.36

Sources of Sophora Root Extract

The plant Sophora Flavescens is a Traditional Chinese Medicine that has been used for anti-tumor, viral hepatitis, enteritis, viral myocarditis, arrhythmia, and skin diseases. It is sometimes referred to as Kushen or Ku Shen, and within the context of Traditional Chinese Medicine is known to have 'cooling' and antiphlogistic (anti-inflammatory) properties.

Sophora flavescens extract is an herbal powder derived from the root of the sophora flavescens plant. It has a long history of medicinal use in China, where it is still used to help treat a wide range of diseases including dysentery, edema and eczema.

Ingredients of Sophora Root Extract

Overall, Sophora Flavescens appears to contain 3.3% Alkaloids and 1.5% Flavanoids.Specific components are:

•Matrine at 0.21-1.12mg/g (seen as the main compound) and Oxymatrine at 1.94-8.77mg/g, as well as the structurally related Sophoridine (0.13-0.62mg/g) and Oxysophorodine

•Isokurarinone and Norkurarinone,both modifications of Kurarinone

•Kurarinol (as well as neokurarinol and norkurarinol

•Kuraidin, Kuraridine, and Kushenol H,K (prenylated flavanoids) and X

•Kushecarpins A-C and Kushinol A-O

•Leachianone G

•L-Maackiain

•Trifolirhizin

•Sophoflavescenol

A variety of bioactives, but Matrine and the related two structures are the most commonly referred to molecules for being 'active' in Sophora Flavescens although some others (the prenylated flavanoids) may be bioactive. 

Specification of Sophora Root Extract

 

Study of Sophora Root Extract

1.Matrine, one of the main components extracted from Sophora flavescens, has displayed anti-cancer activity in several types of cancer cells in vitro.

2.Matrine possesses strong antitumor activities in vitro and in vivo. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities.

3.It promotes hair growth, possibly due to 5-alpha-reductase inhibitory activity.

4.It can reduce the toxicity and adverse effects caused by chemotherapy.

5.It is anti-inflammatory and an antioxidant.

Reference of Sophora Root Extract

1 Yamazaki M.2000. The pharmacological studies on matrine and oxymatrine. Yakugaku Zasshi 120(10) 1025–1033

2 Liu, JY; Hu, JH; Zhu, QG; Li, FQ; Wang, J; Sun, HJ (2007). "Effect of matrine on the expression of substance P receptor and inflammatory cytokines production in human skin keratinocytes and fibroblasts". International immunopharmacology 7 (6): 816–23.

3 Xiao, Ping; Kubo, Hajime; Ohsawa, Masahiro; Higashiyama, Kimio; Nagase, Hiroshi; Yan, Yu-Ning; Li, Jia-Shi; Kamei, Junzo; Ohmiya, Shigeru (1999). "Kappa-Opioid Receptor-Mediated Antinociceptive Effects of Stereoisomers and Derivatives of (+)-Matrine in Mice". Planta Medica 65 (3): 230–3.

4 Li H., Tan G., Jiang X., Qiao H., Pan S., Jiang H., Kanwar J.R., Sun X. "Therapeutic effects of matrine on primary and metastatic breast cancer" Li H., Tan G., Jiang X., Qiao H., Pan S., Jiang H., Kanwar J.R., Sun X. American Journal of Chinese Medicine 2010 38:6 (1115–1130)

5 Liu T., Song Y., Chen H., Pan S., Sun X."Matrine inhibits proliferation and induces apoptosis of pancreatic cancer cells in vitro and in vivo", Biological and Pharmaceutical Bulletin 2010 33:10 (1740–1745)

6 Han Y., Zhang S., Wu J., Yu K., Yu Z., Yin L., Bi L. "Matrine induces apoptosis of human multiple myeloma cells via activation of the mitochondrial pathway", Leukemia and Lymphoma 2010 51:7 (1337–1346)

7 Qin X.-G., Hua Z., Shuang W., Wang Y.-H., Cui Y.-D."Effects of matrine on HepG2 cell proliferation and expression of tumor relevant proteins in vitro", Pharmaceutical Biology 2010 48:3 (275–281)

8 Roh S.-S., Kim C.D., Lee M.-H., Hwang S.-L., Rang M.-J., Yoon Y.-K. "The hair growth promoting effect of Sophora flavescens extract and its molecular regulation" Journal of Dermatological Science 2002 30:1 (43–49)

9 Cha J.-D., Moon S.-E., Kim J.-Y., Jung E.-K., Lee Y.-S. "Antibacterial activity of sophoraflavanone G isolated from the roots of Sophora flavescens against methicillin-resistant Staphylococcus aureus" Phytotherapy Research 2009 23:9 (1326–1331)

10 hang Y., Zhu H., Ye G., Huang C., Yang Y., Chen R., Yu Y., Cui X. Antiviral effects of sophoridine against coxsackievirus B3 and its pharmacokinetics in rats Z Life Sciences 2006 78:17 (1998–2005)

11 Kim J.H., Ryu Y.B., Kang N.S., Lee B.W., Heo J.S., Jeong I.-Y., Park K.H. Glycosidase inhibitory flavonoids from Sophora flavescens Biological and Pharmaceutical Bulletin 2006 29:2 (302–305)