Depending on dosage, yohimbe bark extract can either increase or decrease systemic blood pressure (through vasoconstriction or vasodilation, respectively); small amounts of yohimbine can increase blood pressure, while large amounts can dangerously lower blood pressure.
 

Yohimbe Bark
 

The therapeutic index of yohimbine is quite low; the range between an effective dose and a dangerous dose is very narrow.Perceptible effects begin under half a miligram. A typical dose for sexual dysfunction would be 15–30 mg, whereas 100 mg would be considered dangerous. Overdose may also precipitate panic-type reactions, heart attack, and possibly death. Some have experienced severe adverse effects under 5 mg.

Hallucinations or paralysis may occur with doses greater than 40 mg. Higher doses of oral yohimbine may create numerous side effects, such as rapid heart rate, overstimulation, anomalous blood pressure, cold sweating, and insomnia. In rare cases panic attacks,hallucinations, headaches, dizziness, and skin flushing have occurred.

Overdoses of yohimbine can cause priapism. There is little evidence for the use of pseudoephedrine in the treatment of priapism. The America Urology Association recommends phenylephrine intracavernous injection. In one case report, yohimbine induced priapism was treated with the insertion of a Quackles shunt.

Serious adverse effects of overdose may include seizures and renal failure. Yohimbine should not be consumed by anyone with liver,kidney, or heart disease, or a psychological disorder.
 

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