Yohimbine is an indole alkaloid derived from the bark of the Pausinystalia yohimbe tree in Central Africa. It is primarily used as a treatment for erectile dysfunction. Brand names include: Erex, Testomar, Yocon, Yohimar, Yohimbe. It is a stimulant with aphrodisiac and mildMAOI effects that primarily acts as an antagonist of α2 receptors. It is available as a prescription medication in the standardized form, yohimbine hydrochloride, for the treatment ofxerostomia and selective serotonin reuptake inhibitor induced sexual dysfunction.
 

Yohimbe Bark
 

Yohimbe bark extract application for fat loss

Yohimbine has shown to increase lipolysis in multiple studies.

Administered prior to exercise, it boosts lipolysis and serum FFA levels both during and following exercise; blockade of adipocyte alpha-2 adrenoreceptors makes at least a modest contribution to this pro-lipolytic activity. Pre-exercise yohimbine administration has the potential to down-regulate the lipoprotein lipase activity of visceral adipocytes, increase lipolysis in refractory gynoid fat depots, and improve the impaired lipolytic response to exercise in the elderly.

Combining yohimbine with stimulants such as caffeine and/or ephedrine could possibly further increase lipolysis due to the potential for yohimbine to increase catecholaminergic stimulant activity.

Besides, resveratrol also has the effect of losing weight. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a stilbenoid, a type of natural phenol, and a phytoalexin produced naturally by several plants in response to injury or when the plant is under attack by pathogens such as bacteria or fungi.

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