About Flax Seed Extract
SDG is a plant lignan most notably found in flaxseed (linseed). SDG is classified as a phytoestrogen since it is a plant-derived, nonsteroid compound that possesses estrogen-like activity. SDG has weak estrogenic activity. The level of SDG in flaxseed typically varies between 0.6% and 1.8%.
Lignans are one of the two major classes of phytoestrogens; the other class is the isoflavones. Plant lignans are polyphenolic substances derived from phenylalanine via dimerization of substituted cinnamic alcohols. Mammalian lignans are lignans derived from plant lignans. For example, following ingestion, SDG is converted to the aglycone secoisolariciresinol, which is then metabolized to the mammalian lignans enterolactone and enterodiol. Most of the effects of oral SDG are mediated by enterolactone and enterodiol.
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Product Name |
Flax Seed Extract
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Known As |
Linseed Extract |
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Latin Name |
Linum usitatissimum L. |
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Effective Ingredient |
Lignans 20%, 40%, 50%, 60% |
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PART USED |
Seed |
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Appearance |
Brown yellow fine powder |
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SPECIFICATION |
Lignans 20%, 40%, 50%, 60% Test By HPLC |
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CAS NO. |
148244-82-0 |
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MOLECULAR FORMULA |
C32H46O16 |
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MOLECULAR WEIGHT |
686.71 |
Main fuction:
Flax preventive effect on estrogen-dependent diseases
Flax preventive effect on estrogen-dependent diseases
1. lignans and breast cancer
The study found that lignans by the combined effects of three estradiol synthase (3β- hydroxysteroid dehydrogenase, the enzyme aromatase and 17β- hydroxysteroid oxidoreductase type I) inhibit the synthesis of ovarian estrogen, reducing breast the risk of cancer. Women with breast cancer lignan excretion lower value of urinary excretion of enterolactone values below 1.5μmol / 24h time, have a high risk of breast cancer. Studies have shown: Breast cancer patients daily consumption of 75mg purity of more than 85% of lignans, continuous consumption of three months, 70% of patients the tumor area decreased by 80%, some patients may be substantially recovered.
2. lignans and prostate cancer
Epidemiological survey found that prostate cancer is the most common Western male hormone-related cancers. In Asia, especially residents of soy consumption in the Far East, a large rare disease. The study found lignans enterolactone make between human LNCaP prostate cancer prostate specific antibody levels decline. Lignans enterolactone on 5α-reductase isoenzyme 1 and 2 are inhibited, which leads to reduction of testosterone to 5α-dihydrotestosterone conversion will reduce the role of estrogen in prostate cancer cells, slowing the growth of prostate cancer .
3. lignans and menstrual syndrome
Worldwide there are 11 million women in the absence of estrogen after menopause state spent. Almost all women after menopause, there will be varying degrees of menopausal symptoms. Western countries, especially prominent, but also with a variety of hormone-related diseases (osteoporosis, cardiovascular disease, etc.) significantly increased risk. In the 1990s, the American College of Physicians recommends that pre-menopausal women using hormone replacement therapy (HRT). Studies have shown that long-term use of HRT has a prophylactic benefit, but there has been an increased risk of breast cancer side effects. Thus, people turn naturally occurring in plants phytoestrogens.
4. lignans and osteoporosis
Osteoporosis refers to bone mass per unit volume declined, but its composition ratio remains unchanged. Women with osteoporosis, especially related to menopause, because estrogen loss accelerated bone loss. If a few years the use of hormone replacement therapy in preclinical menopause to prevent bone loss. 1995 World Health Organization to □□□ 70 women over the age of objects survey showed a high bone density population Urinary excretion of phytoestrogens is more, while the phytoestrogen intake and urine excretion were positively correlated, visible phytoestrogen intake and bone mineral density also showed some correlation.
In addition, animal model studies have shown that lignans diabetes, gastrointestinal cancer and coronary heart disease is beneficial.
5. Development and application of lignan
In recent years, Canada, Australia, the UK and the US-based Western countries, flaxseed as a functional food research and development done a lot of work to flaxseed powder represented by products already available for many years, become senile people standing health care products. Recently, the efficacy of compliance with the requirements of high purity, standardized lignan extract products to market, can be widely used in a capsule, tablet, breakfast cereals and snack food additives. Also contain ω-3 fatty acids, nutritional functional soluble dietary fiber and lignans super concentrated emulsions and whole milk beverages and other products emerging in the market. Our current research conducted SDG has come on stream in the corresponding intermediate raw material suppliers have a lot, Xi'an Tianyi Biotechnology Co., Ltd. is currently the SDG major supplier of its products are mainly exported to European and American countries.
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