Product description:
Common name: Corosolic acid
Common name: Corosolic acid
Alias: 2α-hydroxy ursolic acid (2-alpha-hydroxyursolic acid), plant insulin
English name: Corosolic acid
Extraction Source: Eriobotrya japonica Thunb.
Specification: 20%, 98% by HPLC
Appearance: brown to white powder
CAS Number: 4547-24-4
CAS Number: 4547-24-4
Chemical formula: C30H48O4
Molecular weight: 472.7
Structure:
Structure:
Pharmacological effects
1. As a plant insulin, there is hypoglycemic effect
In vitro and in vivo experimental results show that Corosolic acid through the excitement of glucose transport, promote cell absorption and utilization of glucose, in order to achieve its hypoglycemic effect. The excitatory effect of tetraloxic acid on glucose transport is similar to that of insulin, and therefore, cortisol is also known as plant insulin. Animal experiments show that Corosolic acid on normal rats and hereditary diabetic mice have significant hypoglycemic effect.
2. Weight loss, anti-inflammatory and inhibit the role of the tumor
Clinical studies have found that after taking the drug can regulate the body of insulin and blood sugar levels, with a significant trend to lose weight (monthly average weight loss 0.908-1.816Kg), the process is relatively slow and no diet. Corosolic acid also has a variety of other biological activity, such as TPA-induced inflammatory response has a significant inhibitory effect, its anti-inflammatory effect is stronger than the commercial anti-inflammatory indomethacin; it also has DNA polymerase inhibitory activity, As well as the inhibition of a variety of tumor cell growth.
Source plant: Eriobotrya japonica Thunb.
Physical and chemical properties
Corosalic acid is an alpha-olefinic alcohol or oxysilane pentacyclic triterpenoid compound whose basic skeleton is a pentacyclic nucleus of polyhydrogen pin. Corosolic acid can be free in the plant body, can also exist in the form of saponins. In plants, it is often associated with its isomers of hawthornic acid (2α-hydroxy oleanolic acid) co-exist, similar to the structural and chemical properties, separation is difficult.
Corosolic acid is white amorphous powder (methanol), soluble in petroleum ether, benzene, chloroform, pyridine and other organic solvents, insoluble in water, soluble in hot ethanol, methanol. In the absence of water, with strong acid (sulfuric acid, phosphoric acid, perchloric acid), medium acid (trichloroacetic acid) or Lewis acid (zinc chloride, aluminum trichloride, antimony trichloride) role, there will be color reaction Or fluorescent.
Clinical application
At present, the natural product has been listed in the United States as a nutritional supplement, while the treatment of diabetes in three clinical trials, the FDA will be approved by the near future. Its effect on the treatment of diabetes compared with the injection of insulin, with oral effect is obvious, toxic side effects, easy to use, etc., the effect of the same effect with the injection of insulin.
Future outlook
Corosolic acid as a cure for obesity and type II diabetes new drugs and functional natural health food medical raw materials, has become a popular product of the market. With the deepening of research, the product will have a very broad market prospects.
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